Nifurpirinol

SKU: orb1983235

Description

Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish (Chanos chanos) species. Nifurpirinol selectively disrupts the activity of collagen-producing 1alpha2 cells in the Fli//colRN zebrafish line.

Research Area

,Microbiology/Virology|||DNA Damage/DNA Repair

Key Properties

• CAS Number: 13411-16-0
• MW: 246.22
• Purity: 99.70%
• Formula: C₁₂H₁₀N₂O₄
• SMILES: O=[N+]([O-])C1=CC=C(/C=C/C2=CC=CC(CO)=N2)O1

Bioactivity

• In Vivo:
  Strong hyperglycemia was detected in fish treated with Nifurpirinol (523 ±113 mg/dl, n=8) as compared to control fish (65 ±13 mg/dl, n=9). This indicates that NFP is able to induce pancreatic beta cell ablation and thus acts as a substrate for NTR-mediated cell ablation.
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• In Vitro:
  Nifurpirinol-treated larvae show more cell debris and large CFP+ cells with a large cytoplasm and irregular nucleus which are presumably phagocytic cells having engulfed apoptotic CFP neurons. Furthermore, Nifurpirinol-treated larvae display much fewer cells with a normal morphology as compared to MTZ treated larvae, underpinning a more efficient ablation with Nifurpirinol.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

6436061