NOTCH4 (C) Antibody, Rabbit Polyclonal

SKU: orb67113

Description

Rabbit polyclonal to NOTCH4.Neurogenic locus notch homolog protein 4 (NOTCH4) is a single pass membrane protein that belongsto the NOTCH family. NOTCH4 functions as a receptor for membrane-bound ligands Jagged1,Jagged2 and Delta1 to regulate cell-fate determination. NOTCH4 is cleaved upon ligand activationand the notch intracellular domain (NICD) is released, which forms a transcriptional activator complexwith RBPJ/RBPSUH to activate genes of the enhancer of split locus. It affects the implementation ofdifferentiation, proliferation and apoptotic programs.

Research Area

Product Categories/Products/Antibodies,Stem Cells,Epigenetics,Product Categories/Research Area,Developmental Biology,Cardiovascular Disease

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:2000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human NOTCH4
• Molecular Weight: 210
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-NOTCH4 antibody,anti-Neurogenic locus notch homolog protein 4 antibody,anti-Notch 4 antibody,anti-hNotch4 antibody,anti-INT3 antibody

Quick Database Links

UniProt

Q99466