NVS-ZP7-4

SKU: orb654612

Description

NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [2349367-89-9]
• MW: 501.618227958679
• Purity: > 98%,Standard References
• Formula: C₂₈H₂₈FN₅OS
• SMILES: O=C1NC2C=CC=CC=2C2(CCN(C[C@H](CC3C=CC=CC=3)NC3SC4C(=CC=C(C=4)F)N=3)CC2)N1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only