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Olaparib
SKU: orb1304620
Featured
Description
Research Area
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Images & Validation
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Key Properties
−| CAS Number | 763113-22-0 |
|---|---|
| MW | 434.46 |
| Purity | >99.99% (May vary between batches) |
| Formula | C24H23FN4O3 |
| SMILES | C(C=1C=2C(C(=O)NN1)=CC=CC2)C3=CC(C(=O)N4CCN(C(=O)C5CC5)CC4)=C(F)C=C3 |
| Target | Mitophagy, Autophagy, PARP |
| Solubility | 10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (18.41 mM);H2O:< 1 mg/mL (insoluble);DMSO:82.5 mg/mL (189.89 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble) |
Customer Validated Data
− The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Reactivity Distribution
Latest Experiments
16 ResultsDilution
Sample
Summary
In vitro
Human
-
Human ovarian cancer cells (specifically OVCAR 5 line)
It was applied to evaluate its...
In vivo
Mouse
80 or 100 mg/kg
Mice bearing patient-derived xenografts (PDXs)
Olaparib was administered orally to mice...
In vitro
Human
-
Human breast cancer cell lines (MCF7, MDA-MB-231, SK-BR-3, HCC1937, T47D, HCC1806)
Olaparib was dissolved in DMSO and...
In vivo
Mouse
100 mg/kg
BALB/c nude mice bearing subcutaneous MCF7AR or MDA-MB-231 xenografts
Olaparib was dissolved in carboxymethylcellulose sodium...
In vitro
Mouse
30 nM - 30 μM
Murine (Panc02, KPC-A548) pancreatic cancer cell lines
Olaparib were dissolved in DMSO to...
Previous
Storage & Handling
−| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
|---|---|
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−Autophagy, AZD 2281, AZD2281, AZD-2281, PARP, PARP1, PARP2, Mitophagy, Mitochondrial Autophagy, Olaparib, orally, poly ADP ribose polymerase, inhibit, Inhibitor, KU 0059436, KU0059436, KU-0059436
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AZD-2281 (Olaparib) [orb154674]
[763113-22-0]
434.46
C24H23FN4O3
1 ml x 10 mm (in DMSO), 1 g, 100 mg, 250 mg
Quality Guarantee
Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].
Compound Identifiers
PubChem CID
Key Properties
− No computed properties available.
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Protocol Information
Olaparib (orb1304620)
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