Onalespib

SKU: orb1300903

Description

Onalespib

Research Area

Product Categories/Products/Small Molecules,Metabolism|||Cytoskeletal Signaling

Key Properties

• CAS Number: 912999-49-6
• MW: 409.52
• Purity: 99.82%
• Formula: C₂₄H₃₁N₃O₃
• SMILES: CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O

Bioactivity

• Target IC50:
  HSP90 (AT13387):18 nM
• In Vivo:
  AT13387 is a potent inhibitor of the proliferation and survival of many different cell lines from a wide range of different tumor types (e.g., MES-SA cell line). In a panel of 30 tumor cell lines, AT13387 effectively inhibited cell proliferation with GI50 values in the range of 13-260 nM. AT13387 inhibited the proliferation of the non-tumorigenic human prostate epithelial cell line PNT2 with a GI50 value of 480 nM.
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• In Vitro:
  AT13387 is a potent inhibitor of the proliferation and survival of many different cell lines from a wide range of different tumor types (e.g., MES-SA cell line). In a panel of 30 tumor cell lines, AT13387 effectively inhibited cell proliferation with GI50 values in the range of 13-260 nM. AT13387 inhibited the proliferation of the non-tumorigenic human prostate epithelial cell line PNT2 with a GI50 value of 480 nM.
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• Cell Research:
  The human cell lines including A375, 22RV1, T474, DU1 45, LNCa P, MCF-7, DA-MB-468 are seeded into 96-well plates before the addition of AT13387 in 0.1% (v/v) DMSO. GI50 are determined using a 10-point dose response curve for three cell doubling times. After AT13387 incubation 10% (v/v), Alamar blueis added, and cells are incubated for a further 4 hours. Fluorescence is read.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11955716