Pan-HLA Antibody MHC II (DP/DQ/DR)

SKU: orb1823197

Description

Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36kDa) and a beta chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response.

Images & Validation

• Tested Applications: IHC-P
• Dilution Range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Recombinant
• Isotype: Rabbit IgG, kappa
• Clone No.: HLA-Pan/8622R
• Immunogen: Priess cells (a human B cell line) were used as the immunogen for the HLA-DP/DQ/DR antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the HLA-DP/DQ/DR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This HLA-DP/DQ/DR antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

P01920, P01908, P01909, P04440, P01903