PAR-4 Agonist Peptide, amide TFA

SKU: orb1296768

Description

PAR-4 Agonist Peptide, amide TFA

Research Area

Product Categories/Products/Small Molecules,GPCR/G Protein

Key Properties

• CAS Number: 1228078-65-6
• MW: 794.82
• Purity: 100%
• Formula: C₃₆H₄₉F₃N₈O₉
• SMILES: OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

Bioactivity

• In Vivo:
  SCID mice demonstrate a markedly enhanced abdominal response to colorectal distension (CRD), with distension levels ranging from 0.04 to 0.1 mL amplifying the intensity of the EMG response from 384% to 132%, respectively, as compared to BALB/cBy controls (P<0.01; P<0.01; P<0.01; P<0.001). Activation of PAR-4 significantly mitigates this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71311736