PARP-1/2-IN-2

SKU: orb2278404

Description

PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1].

Research Area

,Chromatin/Epigenetic|||DNA Damage/DNA Repair

Key Properties

• MW: 610.41
• Purity: 98.00%
• Formula: C₂₅H₂₃IN₈O₃

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only