PARP1-IN-27

SKU: orb2665398

Description

PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.

Research Area

,Apoptosis|||Chromatin/Epigenetic|||Immunology/Inflammation|||DNA Damage/DNA Repair|||NF-κB|||Metabolism

Key Properties

• MW: 313.28
• Purity: 98.00%
• Formula: C₁₇H₁₂FNO₄

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only