PARP3 Antibody (N-term)

SKU: orb106961

Description

Rabbit polyclonal to PARP3. Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Cancer,Product Categories/Products/Antibodies/Primary Antibodies,Cancer/DNA Damage,Epigenetics,Crown Antibodies;Primary Antibodies;Cell Biology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:1000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB42819
• Immunogen: Synthetic Peptide
• Target: PARP3
• Molecular Weight: 60089
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti PARP3 antibody, anti ADPRT3 antibody, anti ADPRTL3 antibody, anti Poly [ADP-ribose] polymerase 3 antibody, anti Poly [ADP-ribose] polymerase 3 antibody, anti ADP-ribosyltransferase diphtheria toxin-like 3 antibody, anti Poly [ADP-ribose] polymerase 3 antibody, anti IRT1 antibody, anti Poly [ADP-ribose] polymerase 3 antibody, anti NAD(+) ADP-ribosyltransferase 3 antibody, anti Poly [ADP-ribose] polymerase 3 antibody, anti Poly[ADP-ribose] synthase 3 antibody

Quick Database Links

Gene Symbol

PARP3

UniProt

Q9Y6F1

RefSeq (Protein):NP_005476.3, NP_001003931.2