PCC0208017

SKU: orb2279872

Description

PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01?nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7?nM, respectively. PCC0208017 suppresses glioma progression?in?vitro?and?in?vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity?in?vivo?and displays good BBB permeability.

Key Properties

• CAS Number: [2623158-64-3]
• MW: 403.4
• Formula: C₁₉H₂₀F₃N₇
• SMILES: C1(C(NCC2C=CNN=2)=NC(NC2=CC=C3CN(C)CCC3=C2)=NC=1)C(F)(F)F

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only