PEN2 | gamma-secretase subunit PEN-2

SKU: orb303203

Description

Rabbit polyclonal antibody to PEN2

Research Area

Product Categories/Products/Antibodies,Product Categories/Products/Antibodies/Primary Antibodies,Pathology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:250
• Reactivity: Hamster, Human, Mouse
• Predicted Reactivity: Bovine, Rat, Xenopus
• Application Notes:
  One characteristic feature of Alzheimer's disease is the deposition of amyloid-beta peptide (Abeta) as amyloid plaques within specific regions of the human brain. Abeta is derived from the amyloid-beta peptide precursor protein (beta-APP) by the intramembranous cleavage activity of gamma-secretase. PEN-2 (Q9NZ42) is a critical component of PS1/gamma secretase

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Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The antibody was raised against the N-terminal eleven residues of human PEN-2. PEN-2 is the smallest component of the multi-protein gamma-secretase complex. Chosen synthetic peptide has been conjugated to KLH
• Molecular Weight: 15 kDa
• Purity: Immunogen affinity purified serum in PBS pH 7.4.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
• Form/Appearance: Lyophilized
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

UniProt

Q9NZ42