PI3K/AKT-IN-4

SKU: orb2663450

Description

PI3K/AKT-IN-4 (compound 3), a diterpenoid extracted from the roots and rhizomes of Salvia castanea Dielsf., exhibits antitumor properties by inhibiting cell viability and proliferation (IC 50 =4.72 μM) and promoting apoptosis in Hep3B cells. This compound obstructs the G0/G1 phase of the cell cycle, triggers mitochondrial dysfunction, and induces oxidative stress. Moreover, PI3K/AKT-IN-4 combats hepatocellular carcinoma through the inhibition of the PI3K-Akt signaling pathway and by interacting with PARP1 and CDK2 targets.

Research Area

,Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Apoptosis|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair

Key Properties

• MW: 286.41
• Purity: 98.00%
• Formula: C₁₉H₂₆O₂

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only