PIM1 Antibody

SKU: orb38744

Description

Rabbit polyclonal antibody to PIM1 or pim-1 whose expression can be detected in the blood cells but it is majorly expressive in the erythrocytes. It is found in the nucleus. It can perform functions like apoptotic processes and shows oncogenic activity through: the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). It also acts as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Cancer,Neuroscience,Signaling Pathways,Product Categories/Products/Antibodies/Primary Antibodies,Signaling Pathways/Apoptotic,Epigenetics,Primary Antibodies;Cancer;Signal Transduction;Jak-STAT signaling KEGG

Images & Validation

• Tested Applications: IHC-P, WB
• Dilution Range: WB: 1:1000, IHC-P: 1:10-50
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB15686
• Immunogen: Recombinant Protein
• Target: PIM1
• Molecular Weight: 35686
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-Oncogene PIM 1 antibody, anti-Oncogene PIM1 antibody, anti-PIM 1 antibody, anti-pim 1 kinase 44 kDa isoform antibody, anti-Pim 1 kinase antibody, anti-pim 1 oncogene (proviral integration site 1) antibody, anti-Pim 1 oncogene antibody, anti-PIM antibody, anti-PIM1 antibody, anti-pim1 kinase 44 kDa isoform antibody, anti-Proto oncogene serine/threonine protein kinase Pim 1 antibody, anti-Proto-oncogene serine/threonine-protein kinase Pim-1 antibody, anti-Proviral integration site 1 antibody

Quick Database Links

Gene Symbol

PIM1

UniProt

P11309

RefSeq (Protein):NP_002639.1, NP_001230115.1

Xu, Jianwei et al. PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value J Exp Clin Cancer Res, 35, 133 (2016)

PubMed: 27596051