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Osimertinib
SKU: orb1305406
Description
Research Area
Product Categories/Products/Small Molecules,Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Images & Validation
−
Key Properties
−| CAS Number | 1421373-65-0 |
|---|---|
| MW | 499.61 |
| Purity | 99.83% |
| Formula | C28H33N7O2 |
| SMILES | CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)=NC=C3 |
Customer Validated Data
− The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Reactivity Distribution
Latest Experiments
5 ResultsDilution
Sample
Summary
In vitro
Human
-
Recombinant human PDI protein (in vitro) and U2OS human osteosarcoma cells (cellular assays).
Osimertinib was used as a reference/control...
In vitro, In vivo
Human, Mouse
In vitro: 0 to 10 μM. In vivo: 20 mg/kg.
Human (cell lines) and Mouse (xenograft host)
Osimertinib was used both in vitro...
In vitro
Human
-
Human renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLC) cell lines (769-P, SW839, A549, H1299) and their TKI-resistant derivatives.
Osimertinib was used as a control...
In vitro
Mouse
0, 0.01, 0.1, and 1 μM
Mouse Ba/F3 (pro-B cells) and NIH/3T3 (fibroblasts) stably transfected with human EGFR L858R/T790M/L792H or L858R/T790M/G796R triple mutations
Osimertinib was used as a reference/control...
In vitro
Human, Mouse
In virto: 0.25 Μm and 2.7–3.3 μM. In vivo: In vivo: 10 mg/kg
Human (cell lines) and Mouse (xenograft host)
Osimertinib was used as the third-generation...
Storage & Handling
−| Storage | -20°C |
|---|---|
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
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Mereletinib (AZD-9291,Osimertinib) [orb180883]
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Compound Identifiers
PubChem CID
Key Properties
− No computed properties available.
Protocol Information
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