PROTAC GSPT1 degrader-1

SKU: orb2665058

Description

PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC-based degrader that effectively targets and degrades G1 to S phase transition protein 1 (GSPT1), achieving degradation rates of 95% at 1 μM and 86% at 0.1 μM. Additionally, this compound inhibits the viability of HL-60 cells with an IC50 of 9.2 nM.

Research Area

,PROTAC

Key Properties

• CAS Number: 3034310-17-0
• MW: 694.18
• Purity: 98.00%
• Formula: C₃₇H₃₆ClN₇O₅
• SMILES: O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CC(C4)CCN5C(=O)N(C=6C=CC=C(C6)C=7C=NC=8NC=C(C8C7Cl)CC)CCC5)CC1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652593