PSMD2 (N) Antibody, Rabbit Polyclonal

SKU: orb131870

Description

Rabbit polyclonal to PSMD2. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD2 is one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, PSMD2 may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human
• Application Notes:
  < strong>WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; < br>< strong>Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human PSMD2.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human PSMD2
• Molecular Weight: 100
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Concentration: 100 μg/ml BSA
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti 26S proteasome non-ATPase regulatory subunit 2 antibody, anti 26S proteasome regulatory subunit RPN1 antibody, anti 26S proteasome regulatory subunit S2 antibody, anti 26S proteasome subunit p97 antibody, anti Protein 55.11 antibody, anti Tumor necrosis factor type 1 receptor-associated protein 2 antibody, anti TRAP2 antibody, anti MGC14274 antibody, anti P97 antibody, anti Rpn1 antibody, anti S2 antibody

Quick Database Links

UniProt

Q13200