PTC596

SKU: orb654631

Description

PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [1610964-64-1]
• MW: 420.33
• Formula: C₁₉H₁₃F₅N₆
• SMILES: NC1N=C(N2C(C)=NC3C2=CC(=CC=3)F)N=C(NC2C=CC(C(F)(F)F)=CC=2)C=1F

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only