PU-H71 HCl

SKU: orb1819130

Description

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.

Research Area

,Metabolism|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

Key Properties

• CAS Number: 2095432-24-7
• MW: 548.83
• Purity: 98.00%
• Formula: C₁₈H₂₂ClIN₆O₂S
• SMILES: Cl.IC=1C=C2OCOC2=CC1SC3=NC=4C(=NC=NC4N3CCCNC(C)C)N

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

54613037