PXS-6302 hydrochloride

SKU: orb1945022

Description

PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.

Research Area

,Metabolism

Key Properties

• CAS Number: 2584947-79-3
• MW: 301.71
• Purity: 99.89%
• Formula: C₁₀H₁₁ClF₃NO₂S
• SMILES: S(C(/C(=C/CN)/F)(F)F)(=O)(=O)C1=CC=CC=C1.Cl

Bioactivity

• In Vivo:
  PXS-6302 hydrochloride inhibits LOX, reduces cross-linking, and improves the appearance of scars in porcine excision and burn models. In a mouse injury model, topical application of PXS-6302 hydrochloride (1.5%, water-in-oil cream; 500 mg cream applied to 16 cm2; topical; once daily for 28 days) reduces collagen deposition and cross-linked proteins in the fibrotic tissue. Additionally, PXS-6302 hydrochloride (0.5%, 1.5%, or 3%, water-in-oil ointment; 400 mg ointment applied to 16 cm2; topical; once daily for 12 weeks) significantly improves the appearance of scars without reducing tissue strength in a porcine injury model under local application.
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• In Vitro:
  PXS-6302 hydrochloride exhibits high permeability in monolayer cells, such as Caco-2 or MDCKII cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155585071