(R)-Afatinib

SKU: orb1744576

Description

(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM for EGFR L858R/T790M, and 14 nM for HER2, holding potential for research into esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer [1].

Research Area

,Others

Key Properties

• CAS Number: 439081-17-1
• MW: 485.94
• Purity: 98.00%
• Formula: C₂₄H₂₅ClFN₅O₃
• SMILES: N(C=1C2=C(C=C(O[C@@H]3CCOC3)C(NC(C=CCN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

66616893