RAF1 (N) Antibody, Rabbit Polyclonal

SKU: orb67278

Description

Rabbit polyclonal to RAF1.RAF proto-oncogene serine/threonine-protein kinase AF1) belongs to the protein kinasesuperfamily. It acts as a regulatory link between the membrane-associated Ras GTPases and theMAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fatedecisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation.RAF1 can promote NF-kB activation and inhibit signal transducers involved in motility OCK2),apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis B1). It regulates Rhosignaling and migration, and is required for normal wound healing. Defects in RAF1 are the cause ofNoonan syndrome type 5 (NS5) and LEOPARD syndrome type 2 (LEOPARD2).

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies,Cancer,Cardiovascular Disease

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human RAF1
• Molecular Weight: 73
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-RAF1 antibody,anti-RAF protooncogene serine antibody,anti-threonineprotein kinase antibody,anti-cRaf antibody,anti-cRaf antibody,anti-RAF antibody,anti-CRAF antibody,anti-Raf1 antibody,anti-Protooncogene cRAF antibody

Quick Database Links

UniProt

P04049