Randox - Interleukin-33 (IL-33)

SKU: RCP9415

Description

Interleukin 33 (IL-33) is a proimflammatory cytokine belonging to the IL-1 family. IL-33 is cleaved in vivo, generating an N terminal and a C terminal fragment. The C terminal fragment corresponds to the mature IL-33 protein and mediates its biological effect by interacting with the IL-1 receptor, also known as ST2. Binding of mature IL-33 to this receptor activates NF-kappaB and MAP kinases and induces the production of associated cytokines in particular IL-4, IL-5 and IL-13 causing severe pathological changes in mucosal organs

Research Area

,For R&D Purposes

Images & Validation

• Application Notes:
  ELISA, Western Blotting, etc.

Key Properties

• Source: E.coli -derived human recombinant protein
• Expression System: E.coli
• Tag: N terminal containing a HIS tag
• Protein Length: Ser112- Thr270
• MW: 22.49 kDa
• Purity: > 95 %, by SDS-PAGE under reducing conditions

Storage & Handling

• Storage: at -20 °C
• Form/Appearance: Liquid
• Buffer/Preservatives: 10 mM Tris-HCl pH 8, 50% Glycerol
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Interleukin 33; Nuclear factor from high endothelial venules; NFHEV, Chromosone 9 open reading frame 26; C9ORF26; Interleukin-1 family member 11; IL-1F11.

Quick Database Links

UniProt

O95760