Randox - Monoamine Oxidase B (MAOB)

SKU: RCP9307

Description

Monoamine oxidase B (MAO-B) is a flavin-containing mitochondrial enzyme, which catalyzes the oxidative deamination of biogenic and xenobiotic monoamines. It regulates the metabolic degradation of catecholamines and serotonin in neural and other target tissues. MAO-B is found platelets and in dopamine-secreting neurons in the brain. Increased levels of MAO B that have been identified in brain of Alzheimer’s patients. Monoamine oxidases (MAO B and MAO A) are well-known targets for antidepressant drugs and for drugs used to treat neurological disorders and aging diseases, such as Parkinson’s and Alzheimer’s disease.

Research Area

,For R&D Purposes

Images & Validation

• Application Notes:
  ELISA, Western Blotting, etc.

Key Properties

• Source: E.coli -derived human recombinant protein
• Expression System: E.coli
• Tag: N terminal containing a HIS tag
• Protein Length: Ser2- Val489
• MW: 59.84 kDa
• Purity: > 95 %, by SDS-PAGE under reducing conditions

Storage & Handling

• Storage: at -20 °C
• Form/Appearance: Liquid
• Buffer/Preservatives: 25 mM Tris HCl pH 8, 75 mM NaCl, 0.01 mM EDTA, 50% Glycerol
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amine oxidase [flavin-containing] B, Monoamine oxidase type B, MAOB, Mao Platelet, MAO Brain.

Quick Database Links

UniProt

P27338