Rat Eotaxin protein

SKU: orb107707

Description

Eotaxin/CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guineapigs sensitized by aerosol challenge with ovalbumin. Human CCL11 cDNA encodes a 97 amino acid residue precursor proteinfrom which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11.At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11.Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3)has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restrictedsubset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: Eotaxin
• Conjugation: Unconjugated
• MW: 8.4 kDa
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: HPGSIPTSCC FTMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTKLGKEIC ADPKKKWVQDATKHLDQKLQ TPKP

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rat Eotaxin/CCL11 protein

Quick Database Links

Gene Symbol

Eotaxin