Rat FGF-21 protein

SKU: orb107723

Description

Fibroblast growth factor 21 (FGF-21) encoded by the FGF-21 gene belongs to the large FGF family and it is specifically inducedby HMGCS2 activity. In mice, brown adipose tissue becomes a source of systemic FGF-21 after cold exposure. FGF-21stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (butnot SLC2A4/GLUT4 expression) and the activity depends on the presence of KLB. Recombinant rat FGF-21 contains 180 aminoacids residues and show limited binding to heparin. In addition, rat FGF-21 respectively shows 81 % and 92 % a.a. identity tohuman and murine FGF-21, and it show activity on murine and human cells.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: FGF-21
• Conjugation: Unconjugated
• MW: 19.7 kDa
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Protein Sequence: AYPISDSSPL LQFGGQVRQR YLYTDDDQDT EAHLEIREDG TVVGTAHRSPESLLELKALK PGVIQILGVK ASRFLCQQPD GTLYGSPHFD PEACSFRELLLKDGYNVYQS EAHGLPLRLP QKDSQDPATR GPVRFLPMPG LPHEPQEQPGVLPPEPPDVG SSDPLSMVEP LQGRSPSYAS

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, 500 mM NaCl, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rat Fibroblast Growth Factor-21 protein

Quick Database Links

Gene Symbol

FGF-21