Rat IL-33 protein

SKU: orb107761

Description

Interleukin-33 (IL-33), also known as NF-HEV and DVS 27, is a cytokine belonging to the IL-1 superfamily. It is also aproinflammatory protein that may regulate gene transcription and it induces helper T cells, mast cells, eosinophils and basophilsto produce type 2 cytokines. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathologicalchanges observed in mucosal organs following administration of IL-33. IL-33 is constitutively expressed in smooth muscle andairway epithelia and it binds to a high-affinity receptor family member ST2. In vivo administration of mature IL-33 promotesincreased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59 % a.a. and 90 % sequence identity with human andmurine IL-33.

Images & Validation

• Tested Applications: HPLC, SDS-PAGE

Key Properties

• Biological Origin: E.coli
• Target: IL-33
• Conjugation: Unconjugated
• MW: 17.4 kDa
• Purity: > 95 % by SDS-PAGE and HPLC analyses
• Protein Sequence: SIQGTSLLTE SCALSTYNDQ SVSFVLENGC YVINVEDCGK NQEKDKVLLR YYESSFPAQSGDGVDGKKLM VNMSPIKDTD IWLNANDKDY SVELQKGDVS PPDQAFFVLHKKSSDFVSFE CKNLPGTYIG VKDNQLALVE ENDESCNNIM FKLSKM

Storage & Handling

• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, pH 8.5, 3mM beta -mercaptoethanol.
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rat Interleukin-33 protein

Quick Database Links

Gene Symbol

IL-33