RGFP966 (E-isomer)

SKU: orb1819329

Description

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

Research Area

,DNA Damage/DNA Repair|||Chromatin/Epigenetic

Key Properties

• CAS Number: 1396841-57-8
• MW: 362.4
• Purity: 99.10%
• Formula: C₂₁H₁₉FN₄O
• SMILES: Nc1cc(F)ccc1NC(=O)\C=C\c1cnn(CC=Cc2ccccc2)c1

Bioactivity

• Target IC50:
  HDAC3:0.08 μM
• In Vitro:
  In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

68294528