SA-VA

SKU: orb2277876

Description

SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells. This compound undergoes in situ conversion to active PROTAC via a copper-catalyzed click reaction utilizing endogenous copper present in tumor tissues. Additionally, SA-VA induces apoptosis and arrests cell cycle progression in the S phase [1].

Research Area

,PROTAC

Key Properties

• MW: 1044.54
• Purity: 98.00%
• Formula: C₅₀H₅₃ClF₃N₁₁O₇S

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only