Schinifoline

SKU: orb1684918

Description

Schinifoline

Research Area

Product Categories/Products/Small Molecules,Cell Cycle/Checkpoint|||Apoptosis

Key Properties

• CAS Number: 80554-58-1
• MW: 257.37
• Purity: 98%
• Formula: C₁₇H₂₃NO
• SMILES: CN1C=2C(C(=O)C=C1CCCCCCC)=CC=CC2

Bioactivity

• In Vitro:
  This work aimed to investigate the radiosensitizing effect of Schinifoline (SF) on A549 cells. The cell viability results indicated cytotoxicity of SF on A549 cells, with IC50 values of 33.7 ± 2.4, 21.9 ± 1.9 and 16.8 ± 2.2 μg/mL, respectively, after 6, 12, 24 h treatment with different concentrations, and the 10% or 20% IC50 concentration during 12 h was applied in later experiments. The results of cell proliferative inhibition and clonogenic assay showed that SF enhanced the radiosensitivity of A549 cells when applied before 60Co γ-irradiation and this effect was mainly time and concentration dependent. The flow cytometric data indicated that SF treatment before the irradiation increased the G2/M phase, thus improving the radiosensitivity of A549, leading to cell apoptosis.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

133504