SI-113

SKU: orb1298000

Description

SI-113

Research Area

Product Categories/Products/Small Molecules,Metabolism

Key Properties

• CAS Number: 1392816-46-4
• MW: 400.48
• Purity: 98.81%
• Formula: C₂₃H₂₄N₆O
• SMILES: OCCNc1nc(NCCc2ccccc2)c(cnn2C=Cc3ccccc3)c2n1

Bioactivity

• In Vitro:
  Cell viability, cell death, caspase activation and cell cycle progression were then analyzed by FACS and WB-based assays, after exposure to SI113, with or without oxidative stress and ionizing radiations. Moreover, autophagy and related reticulum stress response were evaluated. We show here, that i) SGK1 is over-expressed in highly malignant gliomas and that the treatment with SI113 leads to ii) significant increase in caspase-mediated apoptotic cell death in GBM cell lines but not in normal fibroblasts; iii)enhancement of the effects of ionizing radiations; iv) modulation of the response to oxidative reticulum stress; v) induction of cytotoxic autophagy.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

75971653