SIAIS164018

SKU: orb1982824

Description

SIAIS164018, a PROTAC-based ALK and EGFR degrader derived from Brigatinib, exhibits IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It significantly hampers cancer cell migration and invasion, induces G1 cell cycle arrest, and triggers apoptosis, demonstrating superior properties compared to Brigatinib [1].

Research Area

,Others

Key Properties

• CAS Number: 2353492-68-7
• MW: 883.33
• Purity: 98.00%
• Formula: C₄₃H₄₈ClN₁₀O₇P
• SMILES: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(CC1)C(=O)CNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

141762856