SM-102

SKU: orb1298110

Description

SM-102

Research Area

Product Categories/Products/Small Molecules,Others

Key Properties

• CAS Number: 2089251-47-6
• MW: 710.17
• Purity: 98%
• Formula: C₄₄H₈₇NO₅
• SMILES: CCCCCCCCCCCOC(=O)CCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC

Bioactivity

• Target IC50:
  IK (erg):108 μM|IK (erg) (MA-10 cells):98 μM
• In Vitro:
  METHODS: The effects of SM-102 on ionic currents in two endocrine cells, rat pituitary tumor (GH3) cells and mouse Leydig tumor (MA-10) cells, or microglial cells (BV2), were investigated. Hyperpolarization-activated K currents in these cells bathed in a high-K, Ca2+-free extracellular solution were examined to assess the effects of SM-102 on the amplitude and hysteresis of erg-mediated K currents (I+K(erg)). RESULTS The addition of SM-102 effectively blocked IK(erg) in a concentration-dependent manner with a half-peak concentration (IC50) of 108 μM, which was similar to the KD value required for its enhanced current inactivation time constant (i.e., 134 μM); in the presence of SM-102, exposure of cells to the transfection reagent TurboFectinTM 8.0 (0.1%, v/v) was able to effectively inhibit hyperpolarization-activated IK(erg) and increase the inactivation time course of the current; in addition, in GH3 cells dialyzed with spermine (30 μM), the amplitude of IK(erg) gradually decreased; further use of SM-102 (100 μM) or TurboFectin (0.1%) further reduced the current amplitude; in MA-10 Leydig cells, the IC50 value of SM-102-induced IK(erg) inhibition in MA-10 cells was 98 μM. In BV2 microglia, the amplitude of inwardly rectifying K currents is inhibited by SM-102.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Chemical Structure of orb1298110

Compound Identifiers

PubChem CID

126697616