SMAD3

SKU: orb1818798

Description

SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. Smad3 Inhibitor, SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

Key Properties

• CAS Number: [1009104-85-1]
• MW: 453.532286882401
• Formula: C₂₈H₂₇N₃O₃
• SMILES: CN1C2C(=CC=CN=2)C(/C=C/C(N2CCC3=C(C=C(C(OC)=C3)OC)C2)=O)=C1C1=CC=CC=C1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only