SRX3177

SKU: orb2279790

Description

SRX3177 is a potent, triple BRD4/PI3K/CDK4/6 inhibitor with nanomolar potency against PI3Kα (IC50=79 nM), BRD4 bromodomains (BD1 and BD2) (IC50=33 nM and 89 nM, respectively), and CDK4/6 (IC50=2.5/3.3 nM).SRX3177 is capable of targeting BRD4, PI3K and CDK4/6 simultaneously, induces apoptosis and cell cycle arrest and has in vitro efficacy in mantle cell lymphoma, hepatocellular carcinoma and neuroblastoma models.SRX3177 has antitumor efficacy in in vivo xenograft models and is less toxic than the combination of agents that inhibit individual targets.

Key Properties

• CAS Number: [2241237-51-2]
• MW: 584.688585281372
• Formula: C₃₁H₃₂N₆O₄S
• SMILES: C1(NC2=CC=C(C3C4OC(N5CCOCC5)=CC(=O)C=4SC=3)C=C2)=NC=C2C=C(C(N(C)C)=O)N(C3CCCC3)C2=N1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only