STAT3-IN-18

SKU: orb2277816

Description

STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and exhibits anti-proliferative properties. It promotes apoptosis by activating caspase-3 and elevating levels of cleaved polyADP-ribose polymerase, in addition to enhancing maturation and antigen presentation in dendritic cells. Moreover, STAT3-IN-18 has demonstrated in vivo safety.

Research Area

,Stem Cells|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Chromatin/Epigenetic|||Angiogenesis

Key Properties

• CAS Number: 2668267-41-0
• MW: 630.38
• Purity: 98.00%
• Formula: C₁₈H₂₄Cl₂N₂O₆Pt
• SMILES: C(=C/C1=CC=C(OCC([O-][Pt+4]([Cl-])([Cl-])([NH3])([NH3])[OH-])=O)C=C1)\C2=CC(OC)=CC(OC)=C2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only