STING agonist-4

SKU: orb746431

Description

STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [2138300-40-8]
• MW: 678.758
• Formula: C₃₄H₃₈N₁₂O₄
• SMILES: C(N1C2=CC=C(C(N)=O)C=C2N=C1NC(C1N(CC)N=C(C)C=1)=O)CCCN1C2=CC=C(C(N)=O)C=C2N=C1NC(C1N(CC)N=C(C)C=1)=O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only