SULT1E1 Antibody / Estrogen Sulfotransferase

SKU: orb1825548

Description

The soluble sulfotransferases contribute to the elimination of xenobiotics, the activation of procarcinogens and the regulation of hormones by catalyzing the sulfate conjugation of these substances. SULT1E1, also known as STE, is a 294 amino acid member of the SULT1 family. Localized to the cytoplasm and expressed in intestine, liver and kidney, SULT1E1 exists as a homodimer that is thought to control estrogen receptor (ER) levels by sulfurylating free estradiol. Defects in the gene encoding SULT1E1 are associated with an increased risk for endometrial cancer, suggesting a role for SULT1E1 in tumorigenesis.

Images & Validation

• Tested Applications: IHC-P, WB
• Dilution Range: Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Mouse
• Clonality: Monoclonal
• Isotype: Mouse IgG2, kappa
• Clone No.: SULT1E1/7124
• Immunogen: A recombinant partial protein sequence (within amino acids 100-294) from the human protein was used as the immunogen for the Estrogen Sulfotransferase antibody.
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the Estrogen Sulfotransferase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This Estrogen Sulfotransferase antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

UniProt

P49888