Survivin Antibody / BIRC5

SKU: orb248127

Description

Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.

Research Area

Product Categories/Products/Antibodies,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: Western blot: 2-5ug/ml
• Reactivity: Human
• Application Notes:
  Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Immunogen: A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.
• Purity: Protein A affinity chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Aliquot the antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Buffer/Preservatives: 1X PBS, pH 7.4
• Expiration Date: 12 months from date of receipt.
• Hazard Information: This Survivin antibody is available for research use only.
• Disclaimer: For research use only

Quick Database Links

NCBI Gene ID

332