SYVN1 (M) Antibody, Rabbit Polyclonal

SKU: orb67250

Description

Rabbit polyclonal to SYVN1.E3 ubiquitin-protein ligase synoviolin (SYVN1) is a multi-pass membrane protein that belongs to theHRD1 family. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically fromendoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting theirdegradation. SYVN1 protects cells from ER stress-induced apoptosis and protects neurons fromapoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promotingtheir degradation. It sequesters p53/TP53 in the cytoplasm and promotes its degradation, therebynegatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:2000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: middle region of human SYVN1
• Molecular Weight: 68
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-SYVN1 antibody,anti-E3 ubiquitinprotein ligase synoviolin antibody,anti-Synovial apoptosis inhibitor 1 antibody,anti-HRD1 antibody,anti-KIAA1810 antibody

Western blot analysis of total cell extracts from human Hela using SYVN1 antibody

Quick Database Links

UniProt

Q86TM6