T-518

SKU: orb1818778

Description

T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.T-518 did not obviously inhibit human HDAC1, 4, or 7 at 10 uM, which belongs to Class I or Class IIa HDAC.T-518 showed brain penetration in an oral dose and blocked HDAC6-dependent tubulin deacetylation at Lys40 in mouse hippocampus.T-518 decreased RIPA-insoluble tau accumulation (3-month treatment, 1 and 3 mg/kg), restored impaired axonal transport and novel object recognition in the P301S tau Tg mouse (tauopathy model) by 2-week treatment with dose 1 and 3 mg/kg.

Key Properties

• CAS Number: [2276680-91-0]
• MW: 495.350868225098
• Formula: C₁₉H₁₆F₇N₅O₃
• SMILES: FC(C(F)(F)F)(C(N[C@@H]1CCCC[C@H]1N1C(C2=CC(C3=NN=C(C(F)F)O3)=CN=C2C1)=O)=O)F

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only