TASK1 Potassium Channel Antibody: APC

SKU: orb151064

Description

Mouse monoclonal to TASK1 Potassium Channel (APC). K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels..

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Product Categories/Products/Antibodies/Primary Antibodies,Epigenetics,Neuroscience | Ion Channels | Potassium Channels | Tandem Pore Domain Potassium Channels

Images & Validation

• Tested Applications: ICC, IF, IHC
• Dilution Range: WB (1:1000), ICC/IF (1:100)
• Reactivity: Human, Mouse, Rat
• Application Notes:
  1 µg/ml of SMC-473 was sufficient for detection of TASK1 Potassium Channel in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone No.: N374/48 (Formerly sold as S374-48)
• Immunogen: Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1. Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). < 30% identity with TASK3.
• Target: KCNK3
• Molecular Weight: 50kDa
• Conjugation: APC

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium channel subfamily K member 3 antibody, KCNK3 antibody, Acid sensitive potassium channel protein TASK 1 antibody, Cardiac two pore background K(+) channel antibody, cTBAK 1 antibody, K2p3.1 antibody, KCNK9 antibody, OAT1 antibody, potassium channel subfamily K member 3 antibody, rTASK antibody, TASK 1 antibody, TBAK1 antibody, TWIK related acid sensitive K+ channel antibody, Two pore potassium channel KT3.1 antibody, Two pore K(+) channel KT3.1 antibody

Quick Database Links

Gene Symbol

KCNK3

UniProt

O54912

NCBI Gene ID

29553

RefSeq (Protein):NP_203694.1