Teriflunomide (A-771726)

SKU: orb146201

Description

Teriflunomide: Teriflunomide, aslo know as A77 1726 (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide.

Research Area

Product Categories/Products/Small Molecules,Product Categories/Products/Small Molecules/Inhibitors

Key Properties

• CAS Number: [163451-81-8]
• MW: 270.21
• Formula: C₁₂H₉F₃N₂O₂
• SMILES: C(NC1=CC=C(C(F)(F)F)C=C1)(=O)/C(/C#N)=C(\O)/C

Storage & Handling

• Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
• Hazard Information: Non-Toxic
• Disclaimer: For research use only

Chemical structure of Teriflunomide(A-771726).

References

Groh, Janos et al. Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset Brain Commun, 3, (2021)

PubMed: 33977263

Applications

In vivo

Reactivity

Mouse

Hörner, Michaela et al. CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators Exp Neurol, 355, 114119 (2022)

PubMed: 35605667

Applications

In vivo

Reactivity

Mouse

Groh, Janos et al. Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis Mol Ther, 25, 1889-1899 (2017)

PubMed: 28506594

Applications

In vivo

Reactivity

Mouse