TET1 Antibody, Mouse Monoclonal

SKU: orb66692

Description

Mouse monoclonal to TET1.TET1 is a methylcytosine dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Methylation at the C5 position ofcytosine bases is an epigenetic modification of the mammalian genome which plays an important rolein transcriptional regulation. TET1 might initiate a process leading to cytosine demethylation throughdeamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylatedcytosine by the base excision repair system. TET1 preferentially binds to CpG-rich sequences atpromoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of5mC and 5hmC at gene promoters, it may regulate the gene silencing induced by cytosinemethylation. It has been shown that TET1 plays an important role in embryonic stem cellsmaintenance and regulating the balance between pluripotency and lineage commient.

Research Area

Product Categories/Products/Antibodies,Epigenetics,Product Categories/Products/Antibodies/Primary Antibodies

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Human, Mouse

Key Properties

• Host: Mouse
• Clonality: Monoclonal
• Immunogen: multiple regions of human TET1
• Molecular Weight: 235
• Purity: Ascites
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-TET1 antibody,anti-Methylcytosine dioxygenase TET1 antibody,anti-CXXCtype zinc finger protein 6 antibody,anti-Leukemiaassociated protein with a CXXC domain antibody,anti-Teneleven translocation 1 gene protein antibody,anti-CXXC6 antibody,anti-KIAA1676 antibody,anti-LCX antibody

Western blot analysis of total cell extracts from human Jurkat(Lane1) and mouse thymus(Lane2) using TET1 antibody

Western blot analysis of total cell extracts from mouse thymus using TET1 antibody

Quick Database Links

UniProt

Q8NFU7