TfR-1-IN-1

SKU: orb2663688

Description

TfR-1-IN-1 (compound C4), an inhibitor of transferrin receptor 1 (TfR-1), exhibits potent anticancer properties. This compound notably elevates intracellular iron (II) levels, which serve as a catalyst for ferroptosis induction. Additionally, TfR-1-IN-1 effectively diminishes the metabolic activity in various cancer cell lines, including ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60), with respective IC50 values of 0.51, 0.46, and 0.48 µM.

Research Area

,Apoptosis

Key Properties

• CAS Number: 1643444-62-5
• MW: 441.62
• Purity: 98.00%
• Formula: C₂₀H₁₂ClF₂FeN₂O₂
• SMILES: FC1=CC=CC=2[O-][Fe+3]34([Cl-])[O-]C5=CC=CC(F)=C5C=[N]4C6=CC=CC=C6[N]3=CC12

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only