TICAM1 Antibody (N-term)

SKU: orb134952

Description

Rabbit polyclonal to TICAM1. Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Cancer,Neuroscience,Signaling Pathways,Product Categories/Products/Antibodies/Primary Antibodies,Signaling Pathways/Apoptotic,Immunology,Epigenetics,Infectious Diseases,Crown Antibodies;Primary Antibodies;Immunology;Antiviral defense;Immunity;Inflammatory response;Innate immunity;Toll receptor signaling;Toll-Like receptor signaling

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:1000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Immunogen: Synthetic Peptide
• Target: TICAM1
• Molecular Weight: 76422
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti TICAM1 antibody, anti PRVTIRB antibody, anti TRIF antibody, anti TIR domain-containing adapter molecule 1 antibody, anti TIR domain-containing adapter molecule 1 antibody, anti Proline-rich, vinculin and TIR domain-containing protein B antibody, anti TIR domain-containing adapter molecule 1 antibody, anti Putative NF-kappa-B-activating protein 502H antibody, anti TIR domain-containing adapter molecule 1 antibody, anti Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta antibody

Quick Database Links

Gene Symbol

TICAM1

UniProt

Q8IUC6

RefSeq (Protein):NP_891549.1