TLR4 Antibody: APC

SKU: orb152201

Description

Rabbit polyclonal to TLR4 (APC). The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa..

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Neuroscience,Signaling Pathways,Product Categories/Products/Antibodies/Primary Antibodies,Signaling Pathways/NF-kB,Immunology,Epigenetics,Immunology | Innate Immunity | Macrophage | Immunology | Immunoglobulins | Immunoglobulin Receptors | Cardiovascular System | Atherosclerosis | Vascular Inflammation | Inflammatory Mediators | Immunology | Adaptive Immunity | Regulatory T Cells | Immunology | Innate Immunity | TLR Signaling

Images & Validation

• Tested Applications: ICC, IF, IHC
• Dilution Range: WB (1:500), IHC (1:50)
• Reactivity: Human, Mouse
• Application Notes:
  2 µg/ml of SPC-200 was sufficient for detection of TLR4 in 100 ng of partial recombinant mouse TLR4 protein by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Developed against a synthetic peptide corresponding to amino acids 420-435 of human TLR4
• Target: TLR4
• Molecular Weight: 75-80kDa
• Conjugation: APC

Storage & Handling

• Storage: Conjugated antibodies should be stored according to the product label
• Buffer/Preservatives: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
• Concentration: 1 mg/ml
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARMD10 antibody, CD284 antibody, TLR 4 antibody, TOLL antibody, Toll like receptor 4 antibody

Quick Database Links

Gene Symbol

TLR4

UniProt

O00206

NCBI Gene ID

7099

RefSeq (Protein):NP_612564.1