TSC1 Antibody (Center T417)

SKU: orb106930

Description

Rabbit polyclonal to TSC1. In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.

Research Area

Product Categories/Products/Antibodies,Product Categories/Research Area,Cancer,Product Categories/Products/Antibodies/Primary Antibodies,Epigenetics,Primary Antibodies;Cancer;Cell Biology;Metabolism

Images & Validation

• Tested Applications: WB
• Dilution Range: WB: 1:1000
• Reactivity: Human

Key Properties

• Antibody Type: Primary Antibody
• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Clone No.: RB42204
• Immunogen: Synthetic Peptide
• Target: TSC1
• Molecular Weight: 129767
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti TSC1 antibody, anti KIAA0243 antibody, anti TSC antibody, anti Hamartin antibody, anti Hamartin antibody, anti Tuberous sclerosis 1 protein antibody

Quick Database Links

Gene Symbol

TSC1

UniProt

Q92574

RefSeq (Protein):NP_000359.1, NP_001155898.1, NP_001155899.1