TTC-352

SKU: orb1818865

Description

TTC352 is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.TTC 352 yields an H-bond with Glu353, allows Asp351-to-helix 12 (H12) interaction, sealing ERα's ligand-binding domain, recruiting E2-enriched coactivators, and triggering rapid ERα-induced unfolded protein response (UPR) and apoptosis.TTC-352 is a less potent full estrogen agonist compared to E2, allowing H12 to seal the LBD, which recruits many E2-enriched coactivators, and induces rapid ERα-mediated UPR and apoptosis.

Key Properties

• CAS Number: [1607819-68-0]
• MW: 352.378827810287
• Formula: C₂₀H₁₃FO₃S
• SMILES: S1C(=C(C2C=CC(=CC=2)F)C2C=CC(=CC1=2)O)OC1C=CC(=CC=1)O

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only