UNI418

SKU: orb2665382

Description

UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).

Research Area

,Microbiology/Virology

Key Properties

• CAS Number: 1802068-51-4
• MW: 364.40
• Purity: 98.00%
• Formula: C₂₂H₁₆N₆
• SMILES: N=1C=CC(=CC1)C2=NC3=CC=CC=C3C(=N2)NC4=NNC(=C4)C=5C=CC=CC5

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71295991